Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.51 |
| ▸ | SCN4A | P35499 | 1/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.51 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.51 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.51 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.51 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1593422 | 0.87 | MEN1 (0.74) | POLBKMT2AMEN1S1PR3ALDH1A1 | |
| SCHEMBL1593502 | 0.84 | ALDH1A1 (0.76) | POLBKMT2AMEN1S1PR3ALDH1A1 | |
| SCHEMBL6699009 | 0.81 | POLB (0.69) | POLBKMT2AMEN1S1PR3ALDH1A1 | |
| SCHEMBL7651771 | 0.81 | ALDH1A1 (0.61) | POLBKMT2AMEN1S1PR3ALDH1A1 | |
| SCHEMBL1593930 | 0.78 | ALDH1A1 (0.67) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL7657605 | 0.77 | POLB (0.51) | POLBKMT2AMEN1S1PR3ALDH1A1 | |
| SCHEMBL1383257 | 0.77 | POLB (1.00) | POLBKMT2AMEN1S1PR3L3MBTL1 | |
| SCHEMBL7651873 | 0.74 | KMT2A (0.69) | POLBKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL7649651 | 0.74 | ALDH1A1 (0.65) | POLBKMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL7651042 | 0.74 | ALDH1A1 (0.66) | POLBKMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |