Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI1 | Q9ULC6 | 2/20 | 0.58 |
| ▸ | PADI3 | Q9ULW8 | 2/20 | 0.58 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.58 |
| ▸ | PADI2 | Q9Y2J8 | 2/20 | 0.58 |
| ▸ | TGM2 | P21980 | 1/20 | 0.58 |
| ▸ | S100A4 | P26447 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.50 |
| ▸ | CDC25B | P30305 | 4/20 | 0.49 |
| ▸ | TDP2 | O95551 | 4/20 | 0.48 |
| ▸ | NSD2 | O96028 | 3/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10505905 | 0.87 | S100A4 (0.58) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL12760676 | 0.77 | PADI1 (0.64) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL7648238 | 0.77 | S100A4 (0.68) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL7721595 | 0.76 | PADI1 (0.50) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL31290244 | 0.74 | MALT1 (0.71) | S100A4MEN1KMT2ATHRBBLM | |
| SCHEMBL4539611 | 0.74 | MALT1 (0.71) | S100A4MEN1KMT2ATHRBBLM | |
| SCHEMBL29548274 | 0.74 | S100A4 (0.65) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL21801777 | 0.74 | PADI1 (0.64) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL15552423 | 0.74 | PADI1 (0.64) | PADI1PADI3PADI4PADI2TGM2 | |
| SCHEMBL10507042 | 0.74 | S100A4 (0.65) | PADI1PADI3PADI4PADI2TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148437-A1 | Novel Ezrin Inhibitors and Methods of Making and Using | UNITED STATES GOVERNMENT | 2018-05-31 | — | — | US | disclosed |
| US-20180148437-A1 | Novel Ezrin Inhibitors and Methods of Making and Using | UNITED STATES GOVERNMENT | 2018-05-31 | — | — | US | disclosed |
| US-9522908-B2 | Ezrin inhibitors and methods of making and using | Gerogetown University (US) | 2016-12-20 | — | — | US | disclosed |
| US-9522908-B2 | Ezrin inhibitors and methods of making and using | Gerogetown University (US) | 2016-12-20 | — | — | US | disclosed |
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| WO-2012064396-A9 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2012-07-05 | — | — | WO | disclosed |
| WO-2012064396-A2 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2012-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148437-A1 | Novel Ezrin Inhibitors and Methods of Making and Using | EZR, CDC42, ERMP1 | PADI1 1946/4885PADI3 2005/4885PADI4 2144/4885 |
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | EZR, NHERF1, ERMP1 | PADI1 1715/4885PADI3 2023/4885PADI4 2045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.