Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CRHBP | P24387 | 2/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654953 | 0.85 | MAPT (0.50) | HTTSMN1; SMN2LMNAALDH1A1CRHBP | |
| SCHEMBL1594108 | 0.82 | SMN1; SMN2 (0.56) | HTTSMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL23752483 | 0.80 | SMN1; SMN2 (1.00) | HTTSMN1; SMN2LMNAALDH1A1CRHBP | |
| SCHEMBL4315996 | 0.80 | SMN1; SMN2 (1.00) | HTTSMN1; SMN2LMNAALDH1A1CRHBP | |
| SCHEMBL7652098 | 0.80 | MAPT (0.52) | HTTSMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL7655294 | 0.75 | NPY1R (0.65) | HTTSMN1; SMN2LMNAALDH1A1CRHBP | |
| SCHEMBL7651061 | 0.73 | RAB9A (0.60) | HTTSMN1; SMN2ALDH1A1MAPTHDAC3 | |
| SCHEMBL7752354 | 0.71 | ALDH1A1 (0.82) | HTTSMN1; SMN2LMNAALDH1A1CRHBP | |
| SCHEMBL19074542 | 0.71 | ALDH1A1 (0.82) | HTTSMN1; SMN2LMNAALDH1A1CRHBP | |
| SCHEMBL11615357 | 0.71 | NAMPT (0.69) | HTTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |