Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651646 | 0.85 | HTT (0.67) | MAPTSMN1; SMN2HTTLMNAGFER | |
| SCHEMBL1594108 | 0.83 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2HTTLMNAGFER | |
| SCHEMBL7652098 | 0.81 | MAPT (0.52) | MAPTSMN1; SMN2HTTLMNAGFER | |
| SCHEMBL2183465 | 0.79 | PSEN1 (0.72) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14226463 | 0.76 | LMNA (0.64) | MAPTSMN1; SMN2HTTLMNARAB9A | |
| SCHEMBL3156221 | 0.74 | MAPT (0.74) | MAPTSMN1; SMN2LMNANPSR1RAB9A | |
| SCHEMBL7651061 | 0.74 | RAB9A (0.60) | MAPTSMN1; SMN2HTTGFERNPSR1 | |
| SCHEMBL1821157 | 0.74 | MAPT (0.74) | MAPTSMN1; SMN2LMNANPSR1RAB9A | |
| SCHEMBL1817848 | 0.73 | MEN1 (0.58) | MAPTSMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL14226462 | 0.73 | TSHR (0.57) | MAPTSMN1; SMN2LMNARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |