Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 8/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | HTR1E | P28566 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652829 | 0.80 | LMNA (0.64) | POLBKMT2AMAPTNPSR1USP2 | |
| SCHEMBL1593422 | 0.78 | MEN1 (0.74) | POLBKMT2AMAPTMEN1S1PR3 | |
| SCHEMBL7655884 | 0.78 | KMT2A (0.71) | KMT2AMAPTNPSR1USP2ESR1 | |
| SCHEMBL7652121 | 0.77 | POLB (0.60) | POLBKMT2AMAPTNPSR1USP2 | |
| SCHEMBL7649651 | 0.76 | ALDH1A1 (0.65) | POLBKMT2AMAPTNPSR1USP2 | |
| SCHEMBL7651873 | 0.76 | KMT2A (0.69) | POLBKMT2AMAPTNPSR1USP2 | |
| SCHEMBL8349997 | 0.76 | ALDH1A1 (0.69) | POLBKMT2ANPSR1USP2ESR1 | |
| SCHEMBL1593502 | 0.75 | ALDH1A1 (0.76) | POLBKMT2AMAPTMEN1S1PR3 | |
| SCHEMBL6699009 | 0.75 | POLB (0.69) | POLBKMT2AMAPTNPSR1USP2 | |
| SCHEMBL7651771 | 0.72 | ALDH1A1 (0.61) | POLBKMT2AMAPTNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |