Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7649914 | 0.86 | IGF1R (0.47) | MEN1KMT2ARAD52TP53MAPT | |
| SCHEMBL7649502 | 0.85 | MEN1 (0.47) | MEN1KMT2ARAD52TP53MAPT | |
| SCHEMBL7653795 | 0.84 | SIGMAR1 (0.52) | TP53MAPTCYP1A2CYP2D6TSHR | |
| SCHEMBL7653796 | 0.82 | MAPT (0.50) | MEN1KMT2ARAD52TP53MAPT | |
| SCHEMBL7650324 | 0.82 | MAPT (0.47) | MEN1KMT2ARAD52TP53MAPT | |
| SCHEMBL7649585 | 0.82 | MAPT (0.47) | MEN1KMT2ARAD52TP53MAPT | |
| SCHEMBL7647493 | 0.81 | MAPT (0.49) | MEN1KMT2ARAD52TP53MAPT | |
| SCHEMBL7654933 | 0.81 | MAPT (0.51) | MEN1KMT2ARAD52TP53MAPT | |
| SCHEMBL607287 | 0.80 | MEN1 (0.72) | MEN1KMT2ARAD52TP53MAPT | |
| SCHEMBL7652228 | 0.80 | KMT2A (0.44) | MEN1KMT2ARAD52TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-A1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001029028-A1 | 9- (PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-26 | — | — | WO | disclosed |