Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CCR2 | P41597 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610043 | 0.84 | CCR2 (0.55) | HDAC6HDAC1LMNACCR2SMN1; SMN2 | |
| SCHEMBL451443 | 0.83 | SENP5 (0.44) | PPARGHDAC6HDAC1LMNASMN1; SMN2 | |
| SCHEMBL7606189 | 0.81 | HDAC6 (0.52) | HDAC6HDAC1LMNAMAPTL3MBTL1 | |
| SCHEMBL7609787 | 0.79 | HDAC1 (0.53) | PPARGHDAC6HDAC1LMNASMN1; SMN2 | |
| SCHEMBL7606181 | 0.79 | LRRK2 (0.55) | HDAC6HDAC1MEN1KMT2APOLB | |
| SCHEMBL7606069 | 0.74 | HDAC6 (0.53) | HDAC6HDAC1POLBHDAC8 | |
| SCHEMBL7612625 | 0.72 | SGMS2 (0.50) | HDAC6HDAC1LMNASMN1; SMN2MAPT | |
| SCHEMBL15625856 | 0.72 | MCL1 (0.74) | MCL1 | |
| SCHEMBL7611336 | 0.71 | LRRK2 (0.55) | HDAC6HDAC1MEN1KMT2APOLB | |
| SCHEMBL7613284 | 0.70 | MAPT (0.53) | LMNASMN1; SMN2MAPTL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020068756-A1 | PDE IV inhibiting amides, compositions and methods of treatment | MERCK FROSST CANADA LTD. (CA) | 2002-06-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068756-A1 | PDE IV inhibiting amides, compositions and methods of treatment | PDE3A, PDE3B, PDE4A | PPARG 473/4885HDAC6 59/4885HDAC1 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.