Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.46 |
| ▸ | ITGAV | P06756 | 6/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 5/20 | 0.40 |
| ▸ | CTSK | P43235 | 5/20 | 0.40 |
| ▸ | CTSB | P07858 | 4/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655618 | 0.87 | ITGB3 (0.42) | ITGB3ITGAVITGA2BITGB5LMNA | |
| SCHEMBL382506 | 0.86 | ITGB3 (0.55) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL7651445 | 0.85 | JAK2 (0.38) | ITGB3ITGAVITGA2BAURKALMNA | |
| SCHEMBL7652719 | 0.84 | ITGB3 (0.53) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL7651277 | 0.83 | SLC6A7 (0.47) | ITGB3ITGA2BFLT1KDRFLT3 | |
| SCHEMBL7658395 | 0.83 | HDAC1 (0.39) | ITGB3ITGAVITGA2BITGB5TP53 | |
| SCHEMBL7651202 | 0.81 | ITGB3 (0.53) | ITGB3ITGAVITGA2BITGB5FLT3 | |
| SCHEMBL7658323 | 0.79 | JAK2 (0.41) | ITGB3ITGAVITGA2BFLT3CTSK | |
| SCHEMBL7656748 | 0.79 | TP53 (0.45) | ITGB3ITGAVITGA2BITGB5FLT1 | |
| SCHEMBL382410 | 0.77 | ITGB3 (0.44) | ITGB3ITGAVITGA2BITGB5CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |