Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.36 |
| ▸ | ITGAV | P06756 | 6/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.34 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658383 | 0.83 | ITGB3 (0.49) | HDAC1HDAC8HDAC6JAK2JAK1 | |
| SCHEMBL7652723 | 0.83 | ITGB3 (0.46) | ITGB3ITGAVITGA2BTP53SMN1; SMN2 | |
| SCHEMBL7651445 | 0.82 | JAK2 (0.38) | HDAC6JAK2JAK1JAK3ITGB3 | |
| SCHEMBL7658323 | 0.82 | JAK2 (0.41) | HDAC6JAK2JAK1JAK3ITGB3 | |
| SCHEMBL7651202 | 0.81 | ITGB3 (0.53) | JAK2JAK1JAK3ITGB3ITGAV | |
| SCHEMBL7658303 | 0.72 | ITGB3 (0.49) | HDAC6JAK2JAK1JAK3ITGB3 | |
| SCHEMBL6505653 | 0.72 | ITGB3 (0.48) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL7655207 | 0.71 | ITGB3 (0.42) | ITGB3ITGAVITGA2BALDH1A1 | |
| SCHEMBL7655618 | 0.71 | ITGB3 (0.42) | ITGB3ITGAVITGA2BALDH1A1SMN1; SMN2 | |
| SCHEMBL7651967 | 0.70 | ITGB3 (0.49) | ITGB3ITGAVITGA2BITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |