Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 5/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.52 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 11/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CPN1 | P15169 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22455469 | 0.83 | GRIA1 (0.37) | GRIA1GRIA2GRIA3LMNACYP3A4 | |
| SCHEMBL7469264 | 0.79 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7469005 | 0.79 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7477390 | 0.78 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7469450 | 0.76 | GRIA1 (0.59) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL13812326 | 0.75 | NPY5R (0.40) | GRIA1LMNACYP3A4GABRA1TSHR | |
| Hydrochloric Acid SCHEMBL6409050 | 0.74 | GNAI3 (0.40) | GRIA1LMNACYP3A4GABRA1TSHR | |
| SCHEMBL7474858 | 0.73 | GRIA1 (0.44) | GRIA1GRIA2GRIA3LMNATSHR | |
| SCHEMBL7475447 | 0.73 | GRIA1 (0.47) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL12989697 | 0.73 | SLC6A2 (0.38) | LMNACYP3A4GABRA1TSHRGABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355655-B1 | TREATING A COGNITIVE DISORDER, A NEURO-DEGENERATIVE DISORDER; AGE-RELATED DEMENTIA; AGE-INDUCED MEMORY IMPAIRMENT; A MOVEMENT DISORDER, ATTENTION DEFICIT DISORDER; ATTENTION DEFICIT HYPERACTIVITY DISORDER; PSYCHOSIS; COGNITIVE DEFICITS | ELI LILLY AND COMPANY | 2002-03-12 | — | — | US | disclosed |
| EP-1100498-A4 | HETEROCYCLIC SULPHONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1100498-A1 | HETEROCYCLIC SULPHONAMIDE DERIVATIVES | Eli Lilly & Company (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006159-A1 | HETEROCYCLIC SULPHONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |