Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP7 | P09237 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472680 | 0.77 | GRIA1 (0.40) | GRIA1SMN1; SMN2LMNAMAPK1CTSS | |
| SCHEMBL7469005 | 0.73 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7652792 | 0.73 | GRIA1 (0.52) | GRIA1GRIA2GRIA3LMNAGRIA4 | |
| SCHEMBL7469264 | 0.73 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7477390 | 0.72 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7478571 | 0.71 | CTSS (0.31) | SMN1; SMN2CTSSCTSK | |
| SCHEMBL30666567 | 0.71 | CTSS (0.31) | SMN1; SMN2CTSSCTSK | |
| SCHEMBL30666988 | 0.71 | TRPV3 (0.36) | SMN1; SMN2LMNAMAPK1CTSSCTSK | |
| SCHEMBL7469275 | 0.70 | GRIA2 (0.47) | GRIA1GRIA2GRIA3GRIA4POLB | |
| SCHEMBL7471124 | 0.70 | GRIA2 (0.44) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937708-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | disclosed |
| US-6362230-B1 | ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6174922-B1 | FOR POTENTIATING GLUTAMATE RECEPTOR FUNCTION IN WARM BLOODED MAMMAL | ELI LILLY AND COMPANY | 2001-01-16 | — | — | US | disclosed |
| EP-0937708-A2 | sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |