Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.64 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | SCN1A | P35498 | 1/20 | 0.52 |
| ▸ | SCN4A | P35499 | 1/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31238045 | 0.82 | LMNA (0.55) | LMNAGRM4POLBKMT2AHPGD | |
| SCHEMBL7657605 | 0.80 | POLB (0.51) | LMNAPOLBKMT2ASMN1; SMN2USP2 | |
| Bicarbonate SCHEMBL15225914 | 0.78 | SMN1; SMN2 (0.70) | LMNAGRM4POLBKMT2AHPGD | |
| Bicarbonate SCHEMBL15226101 | 0.78 | KMT2A (0.66) | LMNAGRM4KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL4067862 | 0.78 | KMT2A (0.69) | LMNAGRM4KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8396710 | 0.77 | SMN1; SMN2 (0.78) | LMNAKMT2AHPGDSMN1; SMN2MAPT | |
| SCHEMBL812698 | 0.77 | SMN1; SMN2 (0.78) | LMNAKMT2AHPGDSMN1; SMN2MAPT | |
| SCHEMBL11707518 | 0.77 | SMN1; SMN2 (0.78) | LMNAKMT2AHPGDSMN1; SMN2MAPT | |
| SCHEMBL4067788 | 0.76 | KMT2A (0.68) | LMNAGRM4KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL7655884 | 0.76 | KMT2A (0.71) | LMNAKMT2AUSP2MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |