Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.47 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.47 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | FASN | P49327 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651621 | 0.85 | KCNQ2 (0.47) | KCNQ2SMN1; SMN2KCNQ3CYP1A2TRPV1 | |
| SCHEMBL1593512 | 0.81 | KMT2A (0.58) | KCNQ2SMN1; SMN2KCNQ3TRPV1FASN | |
| SCHEMBL1593906 | 0.80 | KCNQ3 (0.50) | KCNQ2SMN1; SMN2HTTKCNQ3TRPV1 | |
| SCHEMBL7654539 | 0.76 | AOC3 (0.56) | KCNQ2SMN1; SMN2KCNQ3TRPV1ALDH1A1 | |
| SCHEMBL1593432 | 0.75 | KMT2A (0.64) | KCNQ2SMN1; SMN2KCNQ3CYP1A2TRPV1 | |
| SCHEMBL24645772 | 0.74 | MAPT (0.67) | KCNQ2SMN1; SMN2KCNQ3CYP1A2CYP3A4 | |
| SCHEMBL1594391 | 0.73 | KMT2A (0.66) | KCNQ2SMN1; SMN2KCNQ3CYP1A2TRPV1 | |
| SCHEMBL4969527 | 0.71 | KCNQ3 (0.60) | KCNQ2SMN1; SMN2LMNAHTTKCNQ3 | |
| SCHEMBL22777899 | 0.70 | KDM4E (0.60) | KCNQ2HTTKCNQ3TRPV1GAA | |
| SCHEMBL7651646 | 0.70 | HTT (0.67) | KCNQ2SMN1; SMN2LMNAHTTHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |