SCHEMBL7653242

SCHEMBL7653242

Cc1ccc(Br)c(S(=O)O)c1.[NaH]

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.34
RAB9A P51151 4/20 0.33
NPC1 O15118 4/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
TRPA1 O75762 1/20 0.32
KMT2A Q03164 3/20 0.32
MEN1 O00255 2/20 0.32
HSP90AA1 P07900 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
FFAR4 Q5NUL3 1/20 0.31
ALDH1A1 P00352 4/20 0.31
MAPK1 P28482 2/20 0.31
TP53 P04637 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
MAPT P10636 3/20 0.31
HPGD P15428 2/20 0.31
PTPN1 P18031 1/20 0.31
GAA P10253 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2A6 P11509 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5175336 0.98 MAOB (0.35) MAOBRAB9ANPC1SMN1; SMN2TRPA1
SCHEMBL11343549 0.79 ALDH1A1 (0.38) NPC1TRPA1KMT2AMEN1L3MBTL1
SCHEMBL7736962 0.79 TRPA1 (0.37) MAOBSMN1; SMN2TRPA1KMT2AMEN1
SCHEMBL8934344 0.77 ALDH1A1 (0.39) NPC1TRPA1KMT2AMEN1L3MBTL1
SCHEMBL5174995 0.76 NMT1 (0.31) MAOBALDH1A1MAPK1CYP1A2CYP2A6
SCHEMBL11330503 0.75 TDP1 (0.43) RAB9ANPC1SMN1; SMN2TRPA1KMT2A
SCHEMBL8815953 0.73 HTT (0.41) RAB9AL3MBTL1ALDH1A1MAPK1TP53
SCHEMBL10826459 0.73 RAB9A (0.40) RAB9ANPC1KMT2AMEN1ALDH1A1
SCHEMBL7170552 0.72 TDP1 (0.44) RAB9ANPC1SMN1; SMN2TRPA1KMT2A
SCHEMBL8814202 0.71 HTT (0.41) RAB9AL3MBTL1ALDH1A1MAPK1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6372917-B1 INHIBIT CELLULAR SODIUM ION-DEPENDENT CHLORIDE ION/BICARBONATE-EXCHANGE MECHANISM OR SODIUM/BICARBONATE SYMPORTER; TREATMENT OF ALL ACUTE OR CHRONIC DAMAGE CAUSED BY ISCHEMIA OR ILLNESSES INDUCED THEREBY AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-04-16 US disclosed
US-6369236-B1 DRUG FOR MEDICAL DIAGNOSIS ANTIARRHYTHMIC PROPRIETIES AND CONTAIN A CARDIOPROTECTIVE COMPOUND. THEY CAN PREVENTIVELY INHIBIT OR STRONGLY REDUCE PATHOPHYSIOLOGIC PROCESSES UPON OCCURRENCE OF ISCHEMIC INJURIES, ESPECIALLY ISCHEMIC CARDIAC AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-04-09 US disclosed
US-6369069-B1 CARDIOVASCULAR DISORDERS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-04-09 US disclosed