Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CFD | P00746 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950743 | 0.98 | AKR1C3 (0.39) | AKR1C3EHMT2EHMT1KDM4EALDH1A1 | |
| SCHEMBL6767113 | 0.85 | AKR1C3 (0.41) | AKR1C3KDM4EALDH1A1HPGDCASP1 | |
| SCHEMBL6946914 | 0.85 | CFD (0.50) | KDM4EALDH1A1HPGDHSD17B10CFD | |
| SCHEMBL6951033 | 0.84 | AKR1C3 (0.41) | AKR1C3KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6951130 | 0.84 | KDM4E (0.39) | AKR1C3KDM4EALDH1A1HPGDCASP1 | |
| SCHEMBL7654368 | 0.83 | EHMT2 (0.47) | EHMT2EHMT1KDM4EALDH1A1HPGD | |
| SCHEMBL6765566 | 0.82 | AKR1C3 (0.45) | AKR1C3KDM4EALDH1A1HPGDCASP1 | |
| SCHEMBL6765104 | 0.82 | KDM4E (0.40) | AKR1C3KDM4EALDH1A1HPGDCASP1 | |
| SCHEMBL7653518 | 0.81 | CFD (0.50) | KDM4EALDH1A1HPGDHSD17B10CFD | |
| SCHEMBL6772466 | 0.81 | AKR1C3 (0.46) | AKR1C3KDM4EALDH1A1HPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417194-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | PFIZER, INC. | 2002-07-09 | — | — | US | disclosed |
| US-6048864-A | Quinolines and quinazolines useful in therapy | PFIZER INC (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0887344-A1 | Quinolines and quinazolines useful in therapy | Pfizer Limited (GB) | 1998-12-30 | — | — | EP | disclosed |