Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652796 | 0.90 | PKM (0.38) | LMNAHTTSMN1; SMN2KDM4EITGB3 | |
| SCHEMBL7653508 | 0.84 | ITGAV (0.43) | LMNANR3C1NR3C2ITGB3ITGAV | |
| SCHEMBL7652791 | 0.79 | ITGAV (0.54) | ITGB3ITGAVITGA2B | |
| SCHEMBL7655229 | 0.78 | ITGB3 (0.46) | LMNASMN1; SMN2ITGB3ITGAVITGA2B | |
| SCHEMBL7658791 | 0.77 | ITGB3 (0.44) | ITGB3ITGAVITGA2BTSHRMAPT | |
| SCHEMBL6499026 | 0.77 | ITGB3 (0.37) | NR3C1NR3C2ITGB3ITGAVITGA2B | |
| SCHEMBL382346 | 0.75 | ITGB3 (0.46) | LMNAHTTSMN1; SMN2ITGB3ITGAV | |
| SCHEMBL7653366 | 0.72 | MAPT (0.42) | LMNASMN1; SMN2TSHRMAPTNPC1 | |
| SCHEMBL7655263 | 0.70 | DPP4 (0.42) | LMNAHTTSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL7860398 | 0.69 | SMN1; SMN2 (0.36) | LMNAHTTSMN1; SMN2ITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |