Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651891 | 0.99 | HDAC3 (0.48) | KDM4EALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL375579 | 0.82 | ALDH1A1 (0.59) | KDM4EALDH1A1GAAMAPTHPGD | |
| Acetic Acid SCHEMBL28650473 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1HDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL27744263 | 0.81 | ALDH1A1 (0.57) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL11191665 | 0.78 | RAB9A (0.53) | ALDH1A1GAAHPGDNPC1RAB9A | |
| SCHEMBL12799245 | 0.74 | KDM4E (0.52) | KDM4EALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL5670080 | 0.74 | KDM4E (0.52) | KDM4EALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL5670087 | 0.74 | KDM4E (0.52) | KDM4EALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL1341836 | 0.74 | HDAC3 (0.51) | KDM4EALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL29990240 | 0.74 | HDAC3 (0.51) | KDM4EALDH1A1HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |