Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13003254 | 0.82 | MAPK14 (0.44) | MAPK14MAPK1BRD4MAPK7BRD2 | |
| SCHEMBL10273353 | 0.71 | MAPK9 (0.42) | MAPK14MAPK1OPRK1 | |
| SCHEMBL13003262 | 0.71 | MAPK14 (0.44) | MAPK14BRD4MAPK7 | |
| SCHEMBL10273087 | 0.60 | MAPK14 (0.55) | MAPK14MAPK1 | |
| SCHEMBL7698244 | 0.57 | ALDH1A1 (0.71) | MAPK14BRD4MAPK7 | |
| SCHEMBL26686620 | 0.57 | MAPK14 (0.49) | MAPK14MAPK1BRD4MAPK7FLT3 | |
| SCHEMBL26686618 | 0.57 | MAPK14 (0.49) | MAPK14MAPK1BRD4MAPK7FLT3 | |
| SCHEMBL9370469 | 0.57 | OPRK1 (0.46) | OPRK1GSK3B | |
| SCHEMBL17730325 | 0.56 | MERTK (0.55) | MAPK14FLT3GSK3B | |
| SCHEMBL17730328 | 0.56 | MERTK (0.55) | MAPK14FLT3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1439174-B1 | 4-IMIDAZOLIN-2-ONE COMPOUNDS AS p38 MAP KINASE INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | disclosed |