Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 11/20 | 0.46 |
| ▸ | ITGAV | P06756 | 11/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650148 | 0.88 | ITGB3 (0.48) | ITGB3ITGA2BITGAVALDH1A1PKM | |
| SCHEMBL7649933 | 0.85 | NPC1 (0.43) | ITGB3ITGA2BITGAVALDH1A1PKM | |
| SCHEMBL7653737 | 0.83 | ITGB3 (0.52) | ITGB3ITGA2BITGAVITGB1ITGB5 | |
| SCHEMBL7654998 | 0.82 | ITGB3 (0.44) | ITGB3ITGA2BITGAVALDH1A1PKM | |
| SCHEMBL7652576 | 0.81 | ITGB3 (0.45) | ITGB3ITGA2BITGAVALDH1A1PKM | |
| SCHEMBL7651202 | 0.80 | ITGB3 (0.53) | ITGB3ITGA2BITGAVALDH1A1PKM | |
| SCHEMBL7649721 | 0.77 | ITGB3 (0.45) | ITGB3ITGA2BITGAVALDH1A1PKM | |
| SCHEMBL383369 | 0.77 | ITGB3 (0.64) | ITGB3ITGA2BITGAVITGB1ITGB5 | |
| SCHEMBL7651194 | 0.76 | ITGB3 (0.74) | ITGB3ITGA2BITGAV | |
| SCHEMBL7650144 | 0.74 | ITGB3 (0.55) | ITGB3ITGA2BITGAVITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |