Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 9/20 | 0.36 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104707 | 0.85 | PNP (0.36) | PNPKMT2A | |
| SCHEMBL7655696 | 0.82 | P4HTM (0.40) | PNPP4HTMP4HA1MIFMAPK1 | |
| SCHEMBL7654022 | 0.80 | P4HTM (0.35) | P4HTMP4HA1MIFMAPK1KDM4E | |
| SCHEMBL7655707 | 0.79 | P4HTM (0.37) | P4HTMP4HA1MIFMAPK1KDM4E | |
| SCHEMBL7658827 | 0.78 | P4HTM (0.36) | P4HTMP4HA1MIFMAPK1KDM4E | |
| SCHEMBL7110077 | 0.78 | PNP (0.32) | PNP | |
| SCHEMBL7654547 | 0.77 | KMT2A (0.36) | PNPKDM4EL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL7654086 | 0.77 | PNP (0.32) | PNP | |
| SCHEMBL7663905 | 0.77 | CYP1A2 (0.37) | PNPMAPK1KDM4EL3MBTL1KMT2A | |
| SCHEMBL7658471 | 0.73 | ROCK2 (0.39) | P4HTMP4HA1MIFMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |