Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 7/20 | 0.35 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663615 | 0.86 | SIRT6 (0.30) | — | |
| SCHEMBL7655707 | 0.83 | P4HTM (0.37) | P4HTMP4HA1MIFMAPK1MLYCD | |
| SCHEMBL7655696 | 0.81 | P4HTM (0.40) | P4HTMP4HA1MIFMAPK1MLYCD | |
| SCHEMBL7654010 | 0.80 | PNP (0.37) | P4HTMP4HA1MIFMAPK1MLYCD | |
| SCHEMBL7658471 | 0.78 | ROCK2 (0.39) | P4HTMP4HA1MIFMAPK1MLYCD | |
| SCHEMBL7663915 | 0.77 | CYP1A2 (0.36) | MAPK1KDM4EL3MBTL1MAPTNPC1 | |
| SCHEMBL7654556 | 0.77 | KMT2A (0.35) | KDM4EL3MBTL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7650152 | 0.74 | MLYCD (0.42) | P4HTMP4HA1MIFMAPK1MLYCD | |
| SCHEMBL7658827 | 0.71 | P4HTM (0.36) | P4HTMP4HA1MIFMAPK1MLYCD | |
| SCHEMBL7655871 | 0.70 | P4HTM (0.38) | P4HTMP4HA1MIFMAPK1MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |