Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | DDO | Q99489 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654086 | 0.81 | PNP (0.32) | PNP | |
| SCHEMBL7651968 | 0.80 | KDM4E (0.40) | KMT2AKDM4EMEN1ALDH1A1CYP2C9 | |
| SCHEMBL7662443 | 0.78 | KMT2A (0.36) | KMT2AKDM4EMEN1ALDH1A1CYP2C9 | |
| SCHEMBL7104707 | 0.78 | PNP (0.36) | KMT2AMEN1PNP | |
| SCHEMBL7654556 | 0.77 | KMT2A (0.35) | KMT2AKDM4EMEN1ALDH1A1CYP2C9 | |
| SCHEMBL7654010 | 0.77 | PNP (0.37) | KMT2AKDM4EALDH1A1L3MBTL1PNP | |
| SCHEMBL7110077 | 0.77 | PNP (0.32) | PNP | |
| SCHEMBL7651976 | 0.76 | KMT2A (0.37) | KMT2AKDM4EMEN1ALDH1A1CYP2C9 | |
| SCHEMBL7659400 | 0.73 | AKR1C3 (0.39) | KMT2AKDM4EMEN1ALDH1A1CYP2C9 | |
| SCHEMBL7663905 | 0.72 | CYP1A2 (0.37) | KMT2AKDM4EMEN1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |