Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 5/20 | 0.41 |
| ▸ | MAOB | P27338 | 5/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479338 | 0.85 | TDP2 (0.64) | TDP2CRBNTUBB4ATUBBTUBA3C | |
| SCHEMBL7671980 | 0.77 | CRBN (0.55) | MAOAMAOBCRBNBRD4CREBBP | |
| SCHEMBL10711490 | 0.77 | TDP2 (0.75) | TDP2MAOAMAOBCRBNTUBB4A | |
| SCHEMBL7649577 | 0.73 | CRBN (0.45) | TDP2MAOAMAOBCRBNBRD4 | |
| SCHEMBL4019289 | 0.72 | EIF2AK2 (0.63) | TDP2MAOAMAOBCRBNBRD4 | |
| SCHEMBL4406924 | 0.72 | CHEK1 (0.58) | TDP2CRBNBRD4CREBBPEIF2AK2 | |
| SCHEMBL6078702 | 0.71 | S1PR1 (0.53) | TDP2DRD2MAOAMAOBCRBN | |
| SCHEMBL153506 | 0.71 | EIF2AK2 (0.74) | TDP2MAOAMAOBCRBNEIF2AK2 | |
| SCHEMBL4406856 | 0.68 | CRBN (0.57) | TDP2CRBNBRD4CREBBPEIF2AK2 | |
| SCHEMBL1897771 | 0.68 | TDP2 (0.75) | TDP2MAOAMAOBBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255752-A2 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001060814-A2 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 2001-08-23 | — | — | WO | disclosed |