Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 5/20 | 0.39 |
| ▸ | MAOB | P27338 | 5/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463602 | 0.84 | CRBN (0.60) | CRBNBRD4CREBBPCMA1AHR | |
| SCHEMBL7649577 | 0.82 | CRBN (0.45) | CRBNMAOAMAOBBRD4CREBBP | |
| SCHEMBL7654316 | 0.77 | TDP2 (0.49) | CRBNABCB1MAOAMAOBBRD4 | |
| SCHEMBL4509576 | 0.74 | AHR (0.56) | CRBNMAOBBRD4CREBBPCMA1 | |
| SCHEMBL4467816 | 0.71 | CRBN (0.55) | CRBNMAOBBRD4CREBBPCMA1 | |
| SCHEMBL7672998 | 0.71 | GAA (0.53) | — | |
| SCHEMBL23143562 | 0.71 | CRBN (1.00) | CRBNABCB1CMA1AHREIF2AK2 | |
| SCHEMBL6423157 | 0.70 | GAA (0.57) | — | |
| SCHEMBL23143498 | 0.69 | OTUD7B (0.53) | CRBNBRD4CREBBPCMA1AHR | |
| SCHEMBL29899640 | 0.69 | OTUD7B (0.53) | CRBNBRD4CREBBPCMA1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255752-A2 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001060814-A2 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 2001-08-23 | — | — | WO | disclosed |