Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.67 |
| ▸ | HTR2B | P41595 | 8/20 | 0.67 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.54 |
| ▸ | IGF1R | P08069 | 3/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369475 | 0.86 | HTR2C (0.75) | HTR2CHTR2BKDRTRPV1MEN1 | |
| SCHEMBL7375350 | 0.83 | HTR2C (0.74) | HTR2CHTR2BKDRMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL7657753 | 0.81 | HTR2C (0.71) | HTR2CHTR2BKDRTRPV1IGF1R | |
| SCHEMBL7657145 | 0.80 | TRPV1 (0.46) | HTR2CHTR2BKDRTRPV1BRAF | |
| SCHEMBL7369937 | 0.80 | HTR2C (0.70) | HTR2CHTR2BKDRIGF1RMEN1 | |
| Hydrochloric Acid SCHEMBL7664592 | 0.79 | HTR2C (0.98) | HTR2CHTR2BKDRIGF1RMEN1 | |
| Hydrochloric Acid SCHEMBL7657712 | 0.79 | HTR2C (0.69) | HTR2CHTR2BKDRTRPV1IGF1R | |
| SCHEMBL4556067 | 0.79 | KDR (0.75) | KDRTRPV1BRAFMEN1NPC1 | |
| SCHEMBL7371124 | 0.79 | FADS1 (0.67) | HTR2CHTR2BKDRTRPV1MEN1 | |
| SCHEMBL13906661 | 0.78 | NPC1 (0.69) | KDRTRPV1BRAFMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | claimed |
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | disclosed |