Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653377 | 0.89 | KDM4E (0.43) | KDM4EMEN1KMT2ANPSR1GAA | |
| SCHEMBL7653266 | 0.82 | GAA (0.48) | KDM4EGAAPOLBF2RAPGEF4 | |
| SCHEMBL7656229 | 0.79 | GAA (0.46) | KDM4EGAAPOLBF2RAPGEF4 | |
| SCHEMBL7651384 | 0.78 | GAA (0.41) | MEN1KMT2AGAAPOLBF2 | |
| SCHEMBL7657031 | 0.75 | GAA (0.50) | KDM4EGAAPOLBF2RAPGEF4 | |
| SCHEMBL7654407 | 0.75 | GAA (0.46) | KDM4EGAAPOLBF2RAPGEF4 | |
| SCHEMBL7655781 | 0.75 | NSD2 (0.44) | MEN1KMT2AGAAPOLBF2 | |
| SCHEMBL1147984 | 0.74 | CCR1 (0.71) | KDM4ELMNA | |
| SCHEMBL11698648 | 0.73 | GAA (0.47) | GAAPOLBRAPGEF4MAPTLMNA | |
| SCHEMBL7654476 | 0.73 | SMN1; SMN2 (0.45) | KDM4EGAAPOLBF2RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340687-B1 | ELEVATE HIGH DENSITY LIPOPROTEIN CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-22 | — | — | US | disclosed |
| WO-1999011630-A1 | SUBSTITUTED TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE HDL-C ELEVATORS USEFUL AS ANTIATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | disclosed |