Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.42 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672518 | 0.80 | CYP2D6 (0.50) | SMN1; SMN2CYP2D6HPGDTSHRCXCR4 | |
| SCHEMBL7656229 | 0.77 | GAA (0.46) | TSHRALDH1A1LMNAMAPTRAPGEF4 | |
| SCHEMBL12513577 | 0.77 | CXCR4 (0.46) | SMN1; SMN2CYP2D6HPGDTSHRCXCR4 | |
| SCHEMBL7655781 | 0.77 | NSD2 (0.44) | SMN1; SMN2CYP2D6TSHRALDH1A1LMNA | |
| SCHEMBL7653266 | 0.75 | GAA (0.48) | SMN1; SMN2TSHRALDH1A1LMNAMAPT | |
| SCHEMBL14099665 | 0.74 | CXCR4 (0.43) | SMN1; SMN2CYP2D6HPGDTSHRCXCR4 | |
| SCHEMBL7657031 | 0.74 | GAA (0.50) | TSHRALDH1A1LMNAMAPTRAPGEF4 | |
| SCHEMBL7654407 | 0.74 | GAA (0.46) | TSHRALDH1A1HTTLMNAMAPT | |
| SCHEMBL7654451 | 0.73 | KDM4E (0.43) | ALDH1A1LMNAMAPTRAPGEF4KDM4E | |
| SCHEMBL7656975 | 0.72 | GLA (0.44) | SMN1; SMN2CXCR4CXCL12ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340687-B1 | ELEVATE HIGH DENSITY LIPOPROTEIN CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-22 | — | — | US | disclosed |
| WO-1999011630-A1 | SUBSTITUTED TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE HDL-C ELEVATORS USEFUL AS ANTIATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | disclosed |