Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prochlorperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 0.87 |
| ▸ | MAPT | P10636 | 7/20 | 0.90 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.90 |
| ▸ | TP53 | P04637 | 5/20 | 0.90 |
| ▸ | RAD52 | P43351 | 5/20 | 0.90 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.90 |
| ▸ | USP2 | O75604 | 3/20 | 0.90 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.90 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.90 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.90 |
| ▸ | LMNA | P02545 | 7/20 | 0.87 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.87 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.87 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.87 |
| ▸ | HTR2A | P28223 | 6/20 | 0.87 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.87 |
| ▸ | HRH1 | P35367 | 6/20 | 0.87 |
| ▸ | DRD3 | P35462 | 6/20 | 0.87 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prochlorperazine SCHEMBL29089279 | 0.99 | MAPT (0.89) | MAPTMAPK1CYP3A4TP53RAD52 | |
| Prochlorperazine SCHEMBL1527298 | 0.97 | MAPT (0.89) | MAPTMAPK1CYP3A4TP53RAD52 | |
| Prochlorperazine SCHEMBL15511012 | 0.97 | MAPT (0.89) | MAPTMAPK1CYP3A4TP53RAD52 | |
| Prochlorperazine SCHEMBL30903938 | 0.95 | MAPT (1.00) | MAPTMAPK1CYP3A4TP53RAD52 | |
| Prochlorperazine SCHEMBL40855 | 0.95 | MAPT (1.00) | MAPTMAPK1CYP3A4TP53RAD52 | |
| Prochlorperazine SCHEMBL29369439 | 0.93 | DRD2 (1.00) | MAPTMAPK1CYP3A4TP53RAD52 | |
| Prochlorperazine SCHEMBL29358207 | 0.93 | DRD2 (1.00) | MAPTMAPK1CYP3A4TP53RAD52 | |
| Prochlorperazine SCHEMBL18429 | 0.93 | DRD2 (1.00) | MAPTMAPK1CYP3A4TP53RAD52 | |
| Prochlorperazine SCHEMBL14126977 | 0.93 | DRD2 (1.00) | MAPTMAPK1CYP3A4TP53RAD52 | |
| Prochlorperazine SCHEMBL27460359 | 0.93 | MAPT (0.82) | MAPTMAPK1CYP3A4TP53RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4601714-A | Vaginal device | BURNHILL MICHAEL S | 1986-07-22 | — | — | US | disclosed |