Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653392 | 0.86 | P2RX7 (0.39) | P2RX7MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7653034 | 0.82 | P2RX7 (0.36) | P2RX7MEN1KMT2AL3MBTL1 | |
| SCHEMBL7650716 | 0.81 | P2RX7 (0.34) | P2RX7MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7656238 | 0.79 | P2RX7 (0.36) | P2RX7MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7651466 | 0.74 | LMNA (0.38) | P2RX7MEN1KMT2APIK3CDALDH1A1 | |
| SCHEMBL7652049 | 0.74 | HTR2C (0.39) | P2RX7KMT2AL3MBTL1 | |
| SCHEMBL8127545 | 0.71 | P2RX7 (0.38) | P2RX7ALDH1A1TRPA1DRD2DRD3 | |
| SCHEMBL8526757 | 0.62 | MEN1 (0.50) | P2RX7MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL8665062 | 0.61 | MEN1 (0.62) | P2RX7MEN1KMT2A | |
| SCHEMBL11170525 | 0.60 | GAA (0.40) | P2RX7MEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340687-B1 | ELEVATE HIGH DENSITY LIPOPROTEIN CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-22 | — | — | US | claimed |
| WO-1999011630-A1 | SUBSTITUTED TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE HDL-C ELEVATORS USEFUL AS ANTIATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | claimed |
| US-6340687-B1 | ELEVATE HIGH DENSITY LIPOPROTEIN CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-22 | — | — | US | disclosed |
| WO-1999011630-A1 | SUBSTITUTED TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE HDL-C ELEVATORS USEFUL AS ANTIATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | disclosed |