Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 2/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | CDC25C | P30307 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651872 | 1.00 | ALDH1A1 (0.50) | ALDH1A1KDM4ETDP1KMT2AHPGD | |
| SCHEMBL16079372 | 0.79 | PPID (0.54) | ALDH1A1KMT2AATMMAPT | |
| SCHEMBL1731885 | 0.78 | ALDH1A1 (0.50) | ALDH1A1KDM4ETDP1KMT2AHPGD | |
| SCHEMBL16077521 | 0.78 | MEN1 (0.48) | ALDH1A1TDP1KMT2AL3MBTL1 | |
| SCHEMBL7651877 | 0.76 | TDP1 (0.52) | ALDH1A1KDM4ETDP1KMT2APSMB5 | |
| SCHEMBL7654481 | 0.76 | TDP1 (0.52) | ALDH1A1KDM4ETDP1KMT2APSMB5 | |
| SCHEMBL16839711 | 0.75 | TOP2A (0.52) | ALDH1A1KDM4EKMT2AHPGDATM | |
| SCHEMBL845701 | 0.75 | KMT2A (0.62) | ALDH1A1KDM4ETDP1KMT2AHPGD | |
| SCHEMBL29729685 | 0.75 | KMT2A (0.62) | ALDH1A1KDM4ETDP1KMT2AHPGD | |
| SCHEMBL9554924 | 0.74 | MME (0.48) | ALDH1A1KDM4ETDP1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6384061-B1 | HYDANTOIN COMPOUNDS REPRESENTED BY FORMULA (I) WHICH SHOWS AN INHIBITORY ACTIVITY AGAINST FARNESYL TRANSFERASE, AND THUS CAN BE USED AS AN ANTI-CANCER AGENT, OR PHARMACEUTICALLY ACCEPTABLE SALTS | LG CHEMICAL LTD. (KR) | 2002-05-07 | — | — | US | disclosed |
| EP-1000036-A1 | HYDANTOIN DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE | LG CHEMICAL LIMITED (KR) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005117-A1 | HYDANTOIN DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE | LG CHEMICAL LTD. (KR) | 1999-02-04 | — | — | WO | disclosed |