Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 4/20 | 0.44 |
| ▸ | CASP6 | P55212 | 4/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 4/20 | 0.44 |
| ▸ | CASP1 | P29466 | 3/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654481 | 1.00 | TDP1 (0.52) | TDP1KDM4EALDH1A1KMT2APSMB5 | |
| SCHEMBL4878574 | 0.78 | TDP1 (0.67) | TDP1KDM4EALDH1A1KMT2APSMB5 | |
| SCHEMBL4878853 | 0.78 | TDP1 (0.67) | TDP1KDM4EALDH1A1KMT2APSMB5 | |
| SCHEMBL4878561 | 0.78 | TDP1 (0.67) | TDP1KDM4EALDH1A1KMT2APSMB5 | |
| SCHEMBL7654469 | 0.76 | ALDH1A1 (0.50) | TDP1KDM4EALDH1A1KMT2APSMB5 | |
| SCHEMBL7651872 | 0.76 | ALDH1A1 (0.50) | TDP1KDM4EALDH1A1KMT2APSMB5 | |
| SCHEMBL7387704 | 0.76 | CTNNB1 (0.55) | TDP1KDM4EALDH1A1KMT2AMME | |
| SCHEMBL2355800 | 0.75 | CDC25B (0.45) | TDP1KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL9729402 | 0.73 | MAPT (0.40) | TDP1MAPT | |
| SCHEMBL1097611 | 0.72 | KMT2A (0.56) | TDP1KDM4EALDH1A1KMT2APSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6384061-B1 | HYDANTOIN COMPOUNDS REPRESENTED BY FORMULA (I) WHICH SHOWS AN INHIBITORY ACTIVITY AGAINST FARNESYL TRANSFERASE, AND THUS CAN BE USED AS AN ANTI-CANCER AGENT, OR PHARMACEUTICALLY ACCEPTABLE SALTS | LG CHEMICAL LTD. (KR) | 2002-05-07 | — | — | US | disclosed |