Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 6/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658960 | 0.77 | GAA (0.41) | LCKMAPK14 | |
| SCHEMBL7650705 | 0.77 | GAA (0.39) | MAPK14 | |
| SCHEMBL7655803 | 0.75 | MAPK14 (0.40) | GLALCKMAPK14KDM4ESMN1; SMN2 | |
| SCHEMBL7658940 | 0.74 | GAA (0.45) | HTTLCKMAPK14KDM4ELMNA | |
| SCHEMBL7656019 | 0.74 | GAA (0.41) | HTTLCKMAPK14KDM4E | |
| SCHEMBL7655759 | 0.73 | ALDH1A1 (0.37) | NPSR1LCKMAPK14KDM4ELMNA | |
| SCHEMBL7654476 | 0.72 | SMN1; SMN2 (0.45) | HTTCXCR4KDM4ECXCL12OPRL1 | |
| SCHEMBL11662825 | 0.72 | MAPK14 (0.51) | HTTLCKMAPK14KDM4E | |
| SCHEMBL16301207 | 0.72 | SMN1; SMN2 (0.51) | GLAHTTNPSR1MAPK14KDM4E | |
| SCHEMBL7656523 | 0.71 | PTGS2 (0.37) | LCKMAPK14KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340687-B1 | ELEVATE HIGH DENSITY LIPOPROTEIN CHOLESTEROL CONCENTRATION | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-22 | — | — | US | disclosed |
| WO-1999011630-A1 | SUBSTITUTED TETRAHYDRO-PYRIMIDINE-2(1H)-THIONE HDL-C ELEVATORS USEFUL AS ANTIATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | disclosed |