Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 8/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.40 |
| ▸ | PRKCB | P05771 | 2/20 | 0.39 |
| ▸ | PRKCA | P17252 | 2/20 | 0.39 |
| ▸ | PRKCH | P24723 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657926 | 0.95 | USP2 (0.41) | ALDH1A1SMN1; SMN2CA12CA1CA2 | |
| SCHEMBL7851651 | 0.91 | PDE4A (0.38) | CA12CA1CA2CA9PDE4A | |
| SCHEMBL7659856 | 0.91 | PDE4A (0.38) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL7663917 | 0.90 | PDE4A (0.38) | CA12CA1CA2CA9PDE4A | |
| SCHEMBL7662878 | 0.90 | ACKR3 (0.36) | ALDH1A1SMN1; SMN2CA12CA1CA2 | |
| SCHEMBL7664799 | 0.89 | PDE4A (0.37) | CA12CA1CA2CA9PDE4A | |
| SCHEMBL7659626 | 0.87 | CAMK2D (0.43) | ALDH1A1PRKCBPRKCAPRKCHPRKCQ | |
| SCHEMBL7664699 | 0.87 | POLB (0.36) | ALDH1A1SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL7652540 | 0.86 | PDE4A (0.37) | CA12CA1CA2CA9PDE4A | |
| SCHEMBL7662061 | 0.86 | POLB (0.38) | CA12CA1CA2CA9PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458792-B1 | MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. | ASTRAZENECA AB (SE) | 2002-10-01 | — | — | US | disclosed |
| EP-1071683-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999046264-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | disclosed |