Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657926 | 0.92 | USP2 (0.41) | POLBALDH1A1SMN1; SMN2PDE4BPDE4D | |
| SCHEMBL7663837 | 0.88 | TP53 (0.44) | POLBALDH1A1SMN1; SMN2FNTAFNTB | |
| SCHEMBL7654522 | 0.87 | ALDH1A1 (0.42) | POLBALDH1A1SMN1; SMN2PDE4BPDE4D | |
| SCHEMBL7662061 | 0.83 | POLB (0.38) | POLBPDE4BPDE4DLMNAPDE4A | |
| SCHEMBL7666306 | 0.83 | USP2 (0.39) | POLBALDH1A1PDE4BPDE4DLMNA | |
| SCHEMBL7660922 | 0.82 | PDE4A (0.37) | POLBPDE4BPDE4DLMNAPDE4A | |
| SCHEMBL7652540 | 0.82 | PDE4A (0.37) | POLBPDE4BPDE4DLMNAPDE4A | |
| Acetic Acid SCHEMBL7664692 | 0.82 | MEN1 (0.38) | PDE4BPDE4DPDE4APDE4CMEN1 | |
| SCHEMBL8516249 | 0.81 | F2RL3 (0.40) | POLBPDE4BPDE4DLMNAPDE4A | |
| SCHEMBL7662878 | 0.80 | ACKR3 (0.36) | ALDH1A1SMN1; SMN2PDE4BPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458792-B1 | MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. | ASTRAZENECA AB (SE) | 2002-10-01 | — | — | US | claimed |
| US-6458792-B1 | MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. | ASTRAZENECA AB (SE) | 2002-10-01 | — | — | US | disclosed |