Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | CASP3 | P42574 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652131 | 0.81 | CNR1 (0.34) | — | |
| SCHEMBL7653658 | 0.80 | KDM4E (0.44) | KDM4ECASP3ALDH1A1HSD17B10HPGD | |
| SCHEMBL7653650 | 0.78 | KDM4E (0.45) | KDM4ECASP3ALDH1A1HSD17B10HPGD | |
| SCHEMBL7658603 | 0.77 | MME (0.39) | — | |
| SCHEMBL7652930 | 0.77 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL7655301 | 0.76 | ALDH1A1 (0.43) | KDM4EALDH1A1MAPK1POLB | |
| SCHEMBL7654698 | 0.75 | KDM4E (0.44) | KDM4ECASP3ALDH1A1HSD17B10HPGD | |
| SCHEMBL7660893 | 0.74 | KDM4E (0.47) | KDM4ECASP3ALDH1A1HSD17B10HPGD | |
| SCHEMBL7663622 | 0.71 | POLB (0.41) | KDM4EALOX15POLBPTGS2PTGS1 | |
| SCHEMBL9284458 | 0.70 | LMNA (0.38) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |