Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.46 |
| ▸ | SELE | P16581 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658847 | 0.85 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL7661579 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL5909197 | 0.81 | THRB (0.61) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL28309218 | 0.81 | THRB (0.71) | ALDH1A1HSD17B10THRBKMT2AMEN1 | |
| SCHEMBL21211563 | 0.81 | GAA (0.64) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL3400892 | 0.81 | ALDH1A1 (0.49) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL22640849 | 0.79 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10HPGDICAM1 | |
| SCHEMBL22821573 | 0.79 | HPGD (0.48) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL20329603 | 0.79 | ALDH1A1 (0.48) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL7108469 | 0.79 | CNR2 (0.41) | KDM4EALDH1A1HPGDICAM1SELE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |