Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30435368 | 0.92 | ALDH1A1 (0.47) | TDP1ALDH1A1LMNAPDGFRBFGFR1 | |
| SCHEMBL21824100 | 0.86 | ALDH1A1 (0.59) | TDP1ALDH1A1LMNAMAPTATM | |
| SCHEMBL27719772 | 0.86 | PDGFRB (0.56) | TDP1ALDH1A1LMNAPDGFRBFGFR1 | |
| SCHEMBL25314269 | 0.83 | CHEK1 (0.47) | TDP1ALDH1A1LMNAPDGFRBFGFR1 | |
| SCHEMBL7655195 | 0.83 | PDGFRB (0.50) | TDP1ALDH1A1LMNAPDGFRBFGFR1 | |
| SCHEMBL38661659 | 0.82 | CYP1A2 (0.49) | TDP1ALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL2984768 | 0.82 | ALDH1A1 (0.51) | TDP1ALDH1A1LMNAPDGFRBFGFR1 | |
| SCHEMBL2974692 | 0.82 | HCAR3 (0.53) | TDP1ALDH1A1LMNAMAPTMEN1 | |
| SCHEMBL1351134 | 0.81 | LMNA (0.55) | TDP1ALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL4658084 | 0.81 | ALDH1A1 (0.50) | TDP1ALDH1A1LMNAPDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407115-B1 | ANTICARCINOGENIC AND ANTITUMOR AGENTS; SIDE EFFECT REDUCTION, WATER SOLUBILITY | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2002-06-18 | — | — | US | disclosed |
| US-5834476-A | DERIVATIVE OF CAMPTOTHECIN, ANTITUMOR AGENT, ANTICARCINOGENIC AGENT | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5770605-A | Method for treating leukemia with a hexa-cyclic compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-06-23 | — | — | US | disclosed |
| US-5658920-A | ANTITUMOR AGENTS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-08-19 | — | — | US | disclosed |
| US-5637770-A | Hexa-cyclic compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-10 | — | — | US | disclosed |
| EP-0495432-B1 | Hexa-cyclic compound | DAIICHI SEIYAKU CO (JP) | 1996-05-29 | — | — | EP | disclosed |
| EP-0495432-A1 | Hexa-cyclic compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1992-07-22 | — | — | EP | disclosed |