Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.44 |
| ▸ | ITGAV | P06756 | 3/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382676 | 0.86 | ITGB3 (0.52) | ITGB3ITGAVITGA2BTSHRSMN1; SMN2 | |
| SCHEMBL7653324 | 0.85 | ITGB3 (0.46) | KDM4EHTTITGB3ITGAVITGA2B | |
| SCHEMBL7655263 | 0.82 | DPP4 (0.42) | KDM4EHTTTSHRSMN1; SMN2TP53 | |
| SCHEMBL7651633 | 0.82 | NPC1 (0.55) | KDM4EHTTITGB3ITGA2BTSHR | |
| SCHEMBL7655212 | 0.82 | ITGB3 (0.65) | ITGB3ITGAVITGA2B | |
| SCHEMBL7654471 | 0.82 | ITGB3 (0.52) | ITGB3ITGAVITGA2BTSHRSMN1; SMN2 | |
| SCHEMBL7651363 | 0.80 | ITGB3 (0.51) | ITGB3ITGAVITGA2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL7655246 | 0.80 | KDM4E (0.50) | KDM4EHTTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL7651451 | 0.79 | L3MBTL1 (0.53) | KDM4EHTTTSHRSMN1; SMN2TP53 | |
| SCHEMBL7652791 | 0.79 | ITGAV (0.54) | ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |