Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168359 | 0.86 | LMNA (0.54) | LMNASMN1; SMN2PPARGPIK3C2BALDH1A1 | |
| SCHEMBL7659283 | 0.85 | PIK3C2B (0.47) | LMNASMN1; SMN2HSD17B10PPARGPIK3C2B | |
| SCHEMBL6490840 | 0.83 | BCL2 (0.46) | SMN1; SMN2HSD17B10PPARGALDH1A1MAPT | |
| SCHEMBL6490815 | 0.83 | CYSLTR2 (0.41) | LMNASMN1; SMN2PPARGGAAPLA2G2A | |
| SCHEMBL6490551 | 0.82 | PLA2G2A (0.41) | PPARGPLA2G2ATHRB | |
| SCHEMBL6489090 | 0.82 | PPARG (0.43) | LMNASMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL6487667 | 0.80 | PLA2G2A (0.40) | PPARGPLA2G2AMCL1 | |
| SCHEMBL6301191 | 0.80 | PPARG (0.55) | SMN1; SMN2NPC1RAB9APPARGALDH1A1 | |
| SCHEMBL6501647 | 0.80 | PLA2G2A (0.41) | PPARGPLA2G2ATHRB | |
| SCHEMBL6501700 | 0.79 | MCL1 (0.40) | LMNAPPARGALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420409-B1 | GLUCOSE TOLERANCE, DIABETES,INSULIN RESISTANCE, POLYCYSTIC OVARY SYNDROME, HYPERLIPIDEMIA, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS, HYPERGLYCEMIA, HYPERTENSION, STENOCARDIA, PULMONARY HYPERTENSION, CONGESTIVE HEART FAILURE, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |