Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C2B | O00750 | 8/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171656 | 0.85 | PIK3C2B (0.51) | PIK3C2BALOX5APPIK3CBSMN1; SMN2ALDH1A1 | |
| SCHEMBL7656112 | 0.85 | LMNA (0.41) | PIK3C2BSMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL7193408 | 0.83 | PIK3C2B (0.42) | PIK3C2BALOX5APPIK3CBDCTPP1PPARG | |
| SCHEMBL6499333 | 0.83 | BCL2 (0.50) | PIK3C2BALOX5AP | |
| SCHEMBL7196400 | 0.83 | PIK3C2B (0.40) | PIK3C2BPIK3CBDCTPP1PPARG | |
| SCHEMBL7200216 | 0.82 | PIK3C2B (0.41) | PIK3C2BPIK3CBSMN1; SMN2DCTPP1 | |
| SCHEMBL6498814 | 0.81 | S1PR1 (0.39) | PIK3C2BDCTPP1PPARG | |
| SCHEMBL6488966 | 0.80 | RXRA (0.41) | PIK3C2BALOX5APSMN1; SMN2DCTPP1PPARG | |
| SCHEMBL6168359 | 0.80 | LMNA (0.54) | PIK3C2BSMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL6489353 | 0.79 | PIK3C2B (0.38) | PIK3C2BALOX5APSMN1; SMN2LMNADCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420409-B1 | GLUCOSE TOLERANCE, DIABETES,INSULIN RESISTANCE, POLYCYSTIC OVARY SYNDROME, HYPERLIPIDEMIA, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS, HYPERGLYCEMIA, HYPERTENSION, STENOCARDIA, PULMONARY HYPERTENSION, CONGESTIVE HEART FAILURE, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |