Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 5/20 | 0.32 |
| ▸ | HTR1A | P08908 | 4/20 | 0.32 |
| ▸ | HTR1B | P28222 | 4/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7636704 | 0.85 | HSD11B1 (0.34) | CXCR2MAPK14HSD11B1CXCR1HTR1D | |
| SCHEMBL5001561 | 0.78 | MCHR1 (0.38) | MAPK14HSD11B1HTR1DHTR1AHTR1B | |
| SCHEMBL588855 | 0.75 | HSD11B1 (0.40) | HSD11B1HTR1DHTR1AHTR1BDRD2 | |
| SCHEMBL23535040 | 0.72 | CXCR2 (0.36) | CXCR2HSD11B1CXCR1HTR1DHTR1A | |
| SCHEMBL7643485 | 0.72 | HDAC6 (0.52) | MAPK14HSD11B1MCHR1 | |
| SCHEMBL5435745 | 0.69 | MAPK14 (0.49) | MAPK14MCHR1 | |
| SCHEMBL4296439 | 0.67 | SMN1; SMN2 (0.47) | MCHR1 | |
| SCHEMBL589563 | 0.65 | DRD2 (0.38) | HSD11B1HTR1DHTR1AHTR1BDRD2 | |
| SCHEMBL31381607 | 0.64 | ESR2 (0.38) | MCHR1CA1CA2 | |
| SCHEMBL19470175 | 0.63 | ALDH1A1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465495-B1 | INHIBITING DISEASE STATES ASSOCIATED WITH PROTEIN PROTEIN INTERACTION MEDIATED BY A SH2 OR SH3 DOMAIN OR A TYROSINE PHOSPHATASE SUCH AS ALLERGIES, ASTHMA, ANEMIA, AUTOIMMUNE DISEASES, CANCER, INFLAMMATORY DISEASES, OSTEOPOROSIS | OSI PHARMACEUTICALS, INC. | 2002-10-15 | — | — | US | disclosed |