SCHEMBL7656372

SCHEMBL7656372

CCOC(=O)CCCCc1ncc(C#Cc2ccc3c(c2)C(CC)(CC)CCO3)cn1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.38
RARA P10276 1/20 0.38
RARB P10826 1/20 0.38
RARG P13631 1/20 0.38
KMT2A Q03164 1/20 0.38
CYP4F2 P78329 1/20 0.33
CYP4A11 Q02928 1/20 0.33
PTGER4 P35408 3/20 0.32
TBXAS1 P24557 1/20 0.32
BACE1 P56817 3/20 0.32
APP P05067 2/20 0.32
NPC1 O15118 1/20 0.32
TP53 P04637 1/20 0.32
GLA P06280 1/20 0.32
RAB9A P51151 1/20 0.32
BRD4 O60885 1/20 0.31
BACE2 Q9Y5Z0 1/20 0.31
RXRA P19793 1/20 0.30
HNF4A P41235 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6669569 0.91 RARA (0.43) CYP3A4RARARARBRARGKMT2A
SCHEMBL8659605 0.88 RARA (0.41) CYP3A4RARARARBRARGKMT2A
SCHEMBL7649079 0.88 TBXAS1 (0.31) CYP3A4RARARARBRARGKMT2A
SCHEMBL6665905 0.88 CYP3A4 (0.37) CYP3A4RARARARBRARGKMT2A
SCHEMBL8668822 0.87 CYP4Z1 (0.39) CYP3A4RARARARBRARGKMT2A
SCHEMBL8846432 0.86 CYP3A4 (0.40) CYP3A4RARARARBRARGKMT2A
SCHEMBL7654875 0.86 CYP3A4 (0.43) CYP3A4RARARARBRARGKMT2A
SCHEMBL7654888 0.85 NPC1 (0.31) NPC1RAB9A
SCHEMBL7650574 0.84 CYP4F2 (0.32) CYP4F2CYP4A11TBXAS1ALDH1A1
SCHEMBL7657991 0.84 CYP3A4 (0.38) CYP3A4RARARARBRARGKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6344463-B1 SKIN DISORDERS, ACNE ALLERGAN SALES, INC. 2002-02-05 US disclosed
EP-0636127-B1 Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity ALLERGAN INC (US) 2001-04-04 EP disclosed
US-6090826-A Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity ALLERGAN SALES, INC. (US) 2000-07-18 US disclosed
US-5750693-A THIOCHROMANYL OR CHROMANYL COMPOUNDS AS ANTICARCINOGINIC AGENTS, SKIN DISORDERS AND ATHEROSCLEROSIS ALLERGAN (US) 1998-05-12 US disclosed
US-5677451-A CONTROLLING CELL DIFFERENTIATION; SKIN DISORDERS; ANTICANCER AGENTS ALLERGAN (US) 1997-10-14 US disclosed
US-5663347-A REGULATORS OF CELL PROLIFERATION AND DIFFERENTIATION; TREATMENT OF SKIN DISORDERS; ANTICARCINOGNIC AGENTS ALLERGAN (US) 1997-09-02 US disclosed
US-5468879-A Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity ALLERGAN, INC. (US) 1995-11-21 US disclosed
EP-0636127-A1 DISUBSTITUTED ACETYLENES BEARING HETEROBICYCLIC GROUPS AND HETEROAROMATIC OR PHENYL GROUPS HAVING RETINOID LIKE ACTIVITY ALLERGAN, INC. (US) 1995-02-01 EP disclosed
US-5264578-A Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity ALLERGAN, INC. (US) 1993-11-23 US disclosed
WO-1993016068-A1 DISUBSTITUTED ACETYLENES BEARING HETEROBICYCLIC GROUPS AND HETEROAROMATIC OR PHENYL GROUPS HAVING RETINOID LIKE ACTIVITY ALLERGAN, INC. (US) 1993-08-19 WO disclosed