Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 9/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27559931 | 1.00 | CACNA1B (0.38) | CACNA1BMMP1MMP3MMP9TSHR | |
| SCHEMBL6895466 | 0.85 | CACNA1B (0.39) | CACNA1BMMP1MMP3MMP9TSHR | |
| SCHEMBL27570935 | 0.85 | CACNA1B (0.39) | CACNA1BMMP1MMP3MMP9TSHR | |
| SCHEMBL6890733 | 0.85 | HSD17B10 (0.47) | ALDH1A1HSD17B10 | |
| SCHEMBL6897614 | 0.85 | HSD17B10 (0.43) | CACNA1BMMP1MMP3MMP9CTSK | |
| SCHEMBL27538348 | 0.85 | HSD17B10 (0.43) | CACNA1BMMP1MMP3MMP9CTSK | |
| SCHEMBL7656431 | 0.81 | MC4R (0.31) | — | |
| SCHEMBL6894683 | 0.78 | MMP2 (0.39) | MMP1MMP3MMP9ALDH1A1 | |
| SCHEMBL6898797 | 0.76 | HTR1A (0.33) | KDM4EALDH1A1HTR1AHSD17B10 | |
| SCHEMBL6899406 | 0.75 | KDM4E (0.34) | KDM4EALDH1A1HTR1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492370-B1 | Urea derivatives and pharmaceutical compositions thereof | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-10 | — | — | US | disclosed |
| CN-1299344-A | Novel urea derivatives | SANTEN PHARCEUMATICAL CO LTD (JP) | 2001-06-13 | — | — | CN | disclosed |
| EP-1072591-A1 | NOVEL UREA DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-01-31 | — | — | EP | disclosed |