Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | HPGD | P15428 | 2/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | ATM | Q13315 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.67 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.67 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.67 |
| ▸ | MAOB | P27338 | 4/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.63 |
| ▸ | DPP4 | P27487 | 1/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4139154 | 0.92 | GABRA3 (0.78) | MAPTLMNAHPGDSMN1; SMN2GABRA3 | |
| SCHEMBL28339980 | 0.92 | GABRA3 (0.78) | MAPTLMNAHPGDSMN1; SMN2GABRA3 | |
| SCHEMBL5607166 | 0.86 | MAPT (1.00) | MAPTLMNAHPGDL3MBTL1KDM4E | |
| SCHEMBL5607164 | 0.86 | MAPT (1.00) | MAPTLMNAHPGDL3MBTL1KDM4E | |
| SCHEMBL1576913 | 0.86 | MAPT (0.75) | MAPTLMNAL3MBTL1ATMSMN1; SMN2 | |
| SCHEMBL1576914 | 0.86 | MAPT (0.75) | MAPTLMNAL3MBTL1ATMSMN1; SMN2 | |
| SCHEMBL1603827 | 0.86 | CHRNA7 (0.75) | MAPTGABRA3GABRA2GABRB2TNFRSF1A | |
| SCHEMBL1603828 | 0.86 | CHRNA7 (0.75) | MAPTGABRA3GABRA2GABRB2TNFRSF1A | |
| SCHEMBL19182870 | 0.84 | LMNA (1.00) | MAPTLMNAHPGDL3MBTL1KDM4E | |
| SCHEMBL19182869 | 0.84 | LMNA (1.00) | MAPTLMNAHPGDL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500846-B1 | 2-(4-CHLOROPHENYL)-7-METHOXYCHROMEN-4-ONE, AS CYCLIN-DEPENDENT KINASE INHIBITORS, USED AS ANTICARCINOGENIC AGENTS OR FOR PROPHYLAXIS OF NEURODEGENERATIVE DISEASE | LG CHEMICAL, LTD. (KR) | 2002-12-31 | — | — | US | disclosed |
| EP-1109800-A1 | NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE | LG CHEMICAL LIMITED (KR) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012496-A1 | NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE | LG CHEMICAL LTD. (KR) | 2000-03-09 | — | — | WO | disclosed |