Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663932 | 0.87 | ALDH1A1 (0.44) | ALDH1A1KDM4EPRMT5NPC1RAB9A | |
| SCHEMBL7661497 | 0.86 | ALDH1A1 (0.46) | ALDH1A1KDM4ENPC1RAB9AP4HTM | |
| SCHEMBL6388225 | 0.84 | HDAC1 (0.49) | ALDH1A1KDM4ENPC1RAB9AP4HTM | |
| SCHEMBL7105165 | 0.84 | MAP2K1 (0.41) | ALDH1A1KDM4EHPGDMAP2K1 | |
| SCHEMBL8824679 | 0.84 | THRB (0.54) | ALDH1A1KDM4ENPC1RAB9AP4HTM | |
| SCHEMBL24336711 | 0.80 | GABRA5 (0.44) | ALDH1A1KDM4EHPGDGABRA5PRMT5 | |
| SCHEMBL21365172 | 0.80 | GABRA5 (0.44) | ALDH1A1KDM4EHPGDGABRA5PRMT5 | |
| SCHEMBL19878599 | 0.80 | GABRA5 (0.44) | ALDH1A1KDM4EHPGDGABRA5PRMT5 | |
| SCHEMBL19878598 | 0.80 | GABRA5 (0.44) | ALDH1A1KDM4EHPGDGABRA5PRMT5 | |
| SCHEMBL8061648 | 0.80 | ALDH1A1 (0.42) | ALDH1A1KDM4EGABRA5PRMT5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |