Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666397 | 0.81 | KMT2A (0.40) | KMT2ARAB9ANPC1SMN1; SMN2PDE5A | |
| SCHEMBL7661646 | 0.77 | TLR7 (0.41) | KMT2ARAB9ANPC1SMN1; SMN2PDE5A | |
| SCHEMBL7671571 | 0.76 | TLR7 (0.45) | PDE4BKMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8560623 | 0.76 | KMT2A (0.41) | KMT2ARAB9ANPC1SMN1; SMN2PDE5A | |
| SCHEMBL6996208 | 0.73 | PDE5A (0.47) | KMT2ARAB9ANPC1SMN1; SMN2PDE5A | |
| SCHEMBL7003070 | 0.71 | PDE5A (0.48) | PDE4BKMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7003453 | 0.70 | PDE5A (0.45) | KMT2ARAB9ANPC1SMN1; SMN2PDE5A | |
| SCHEMBL6999063 | 0.69 | KMT2A (0.48) | PDE4BKMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7001362 | 0.69 | KMT2A (0.48) | KMT2ARAB9ANPC1SMN1; SMN2PDE5A | |
| SCHEMBL6996654 | 0.68 | KMT2A (0.46) | KMT2ARAB9ANPC1SMN1; SMN2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492377-B1 | Imidazotriazolopyrimidines with adenosine-antagonistic activity | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |