Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668666 | 0.88 | POLB (0.47) | TLR7POLBMAPK1NPSR1BLM | |
| SCHEMBL7661646 | 0.87 | TLR7 (0.41) | TLR7POLBMAPK1NPSR1BLM | |
| SCHEMBL7666397 | 0.82 | KMT2A (0.40) | TLR7PDE5ANPC1SMN1; SMN2RAB9A | |
| SCHEMBL8560623 | 0.77 | KMT2A (0.41) | TLR7PDE5ANPC1SMN1; SMN2RAB9A | |
| SCHEMBL7656794 | 0.76 | PDE4B (0.40) | TLR7PDE5ANPC1TSHRSMN1; SMN2 | |
| SCHEMBL7662109 | 0.75 | ADORA1 (0.48) | TSHRLMNAKMT2AMEN1ADORA3 | |
| SCHEMBL7006028 | 0.74 | KMT2A (0.45) | POLBMAPK1NPSR1BLMCTDSP1 | |
| SCHEMBL8567698 | 0.73 | ADORA1 (0.48) | TSHRLMNAKMT2AMEN1ADORA3 | |
| SCHEMBL7003070 | 0.71 | PDE5A (0.48) | POLBMAPK1NPSR1BLMCTDSP1 | |
| SCHEMBL7003073 | 0.71 | PDE1B (0.36) | POLBPDE5AATMLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492377-B1 | Imidazotriazolopyrimidines with adenosine-antagonistic activity | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |