Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215155 | 0.80 | PARP1 (0.38) | PARP1MAPK8 | |
| SCHEMBL7214410 | 0.73 | PARP1 (0.54) | PARP1MAPK8ALDH1A1MAPTHPGD | |
| SCHEMBL10818516 | 0.60 | IKBKB (0.45) | PARP1PDK2IKBKBUSP2ALDH1A1 | |
| SCHEMBL21666346 | 0.59 | KDM4E (0.43) | PARP1PDK2IKBKBALDH1A1MAPT | |
| SCHEMBL6369200 | 0.59 | PARP1 (0.44) | PARP1MAPK8ALDH1A1MAPTHPGD | |
| SCHEMBL8295673 | 0.58 | PARP1 (0.39) | PARP1MAPK8ALDH1A1HPGDHSD17B10 | |
| SCHEMBL8295684 | 0.57 | MAPK8 (0.43) | PARP1MAPK8MAPTHPGD | |
| SCHEMBL19380525 | 0.57 | TSHR (0.42) | PARP1MAPK8ALDH1A1HPGDTSHR | |
| SCHEMBL1913451 | 0.57 | TRPA1 (0.55) | PARP1IKBKBUSP2ALDH1A1MAPT | |
| SCHEMBL4097033 | 0.57 | ALDH1A1 (0.54) | PARP1PDK2IKBKBUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6482852-B2 | UE TREATING PROLIFERATIVE DISEASE, CANCER, RESTENOSIS, OSTEOPOROSIS, INFLAMMATION, ALLERGIES, OR CARDIOVASCULAR DISEASE; INHIBITION OF SH2-MEDIATED SIGNALING | ARIAD PHARMACEUTICALS, INC. | 2002-11-19 | — | — | US | disclosed |