Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.63 |
| ▸ | PPARA | Q07869 | 13/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 11/20 | 0.63 |
| ▸ | PTGES | O14684 | 11/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656991 | 0.90 | PPARG (0.56) | PPARGPPARAALOX5PTGES | |
| Hydroxyamine SCHEMBL7557063 | 0.89 | ALOX5 (0.52) | PPARGPPARAALOX5PTGES | |
| SCHEMBL6932495 | 0.88 | MMP9 (0.55) | PPARGPPARAALOX5PTGES | |
| SCHEMBL8356987 | 0.83 | PPARG (0.64) | PPARGPPARAALOX5PTGES | |
| SCHEMBL9099026 | 0.83 | PPARG (0.64) | PPARGPPARAALOX5PTGES | |
| SCHEMBL9099036 | 0.83 | PPARG (0.64) | PPARGPPARAALOX5PTGES | |
| SCHEMBL22612343 | 0.83 | PPARG (0.64) | PPARGPPARAALOX5PTGES | |
| SCHEMBL5081085 | 0.82 | PPARG (0.66) | PPARGPPARAALOX5PTGES | |
| Hydroxyamine SCHEMBL7551596 | 0.79 | PPARG (0.46) | PPARGPPARAALOX5PTGES | |
| Hydroxyamine SCHEMBL7465088 | 0.78 | PPARG (0.63) | PPARGPPARAALOX5PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462073-B2 | METALLOPROTEASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION | 2002-10-08 | — | — | US | disclosed |
| US-6331563-B1 | LOW MOLECULAR WEIGHT, NON-PEPTIDE INHIBITORS OF MATRIX METALLOPROTEINASES AND TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME; TREATING ARTHRITIS, TUMOR METASTASIS, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, INSULIN RESISTANCE | WYETH HOLDINGS CORPORATION | 2001-12-18 | — | — | US | disclosed |