Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7966821 | 0.98 | OPRM1 (0.50) | OPRM1ADRA1AADRA1DADRA1BSIGMAR1 | |
| SCHEMBL10528035 | 0.87 | ADRA1A (0.43) | OPRM1ADRA1AADRA1DADRA1B | |
| SCHEMBL31459412 | 0.87 | ADRA1A (0.43) | OPRM1ADRA1AADRA1DADRA1B | |
| SCHEMBL624164 | 0.84 | ADRA1A (0.41) | OPRM1ADRA1AADRA1DADRA1B | |
| SCHEMBL18764271 | 0.82 | HDAC4 (0.44) | OPRM1ADRA1AADRA1DADRA1B | |
| SCHEMBL181276 | 0.82 | HDAC4 (0.44) | OPRM1ADRA1AADRA1DADRA1B | |
| SCHEMBL6911353 | 0.81 | SIGMAR1 (0.39) | OPRM1SIGMAR1HTR2C | |
| SCHEMBL30338086 | 0.81 | OPRM1 (0.37) | OPRM1SIGMAR1HTR2C | |
| SCHEMBL615034 | 0.81 | OPRM1 (0.37) | OPRM1SIGMAR1HTR2C | |
| SCHEMBL1766226 | 0.79 | OPRM1 (0.36) | OPRM1SIGMAR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922722-A | PIPERIDINE OR PIPERAZINE DERIVATIVES TO TREAT BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. (US) | 1999-07-13 | — | — | US | claimed |
| EP-0865280-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-09-23 | — | — | EP | claimed |
| WO-1997017967-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-05-22 | — | — | WO | claimed |
| WO-2012158475-A1 | N-LINKED LACTAM M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2012-11-22 | — | — | WO | disclosed |
| US-6436962-B1 | ALPHA 1A ADRENERGIC RECEPTOR ANTAGONISTS; RELIEF FROM BENIGN PROSTATIC HYPERPLASIA BY LESS HINDERED URINE FLOW BY RELAXING SMOOTH MUSCLE TISSUE; WITH A TESTOSTERONE 5-ALPHA REDUCTASE INHIBITOR, FINASTERIDE; ACUTE AND CHRONIC RELIEF | MERCK & CO., INC. | 2002-08-20 | — | — | US | disclosed |
| US-6274583-B1 | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. | 2001-08-14 | — | — | US | disclosed |
| US-5977115-A | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| US-5922722-A | PIPERIDINE OR PIPERAZINE DERIVATIVES TO TREAT BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. (US) | 1999-07-13 | — | — | US | disclosed |
| EP-0865280-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-09-23 | — | — | EP | disclosed |
| EP-0833637-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST | MERCK & CO INC (US) | 1998-07-08 | — | — | EP | disclosed |
| EP-0833637-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997017967-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-05-22 | — | — | WO | disclosed |
| WO-1996040136-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |